沈立轲,男,理学博士,副教授,硕士生导师,主要研究植物细胞离子通道、转运体在植物响应非生物逆境(如盐胁迫和营养胁迫等)过程中的生理功能和调控机制,旨在提高作物的耐盐性和养分利用效率。以通讯作者或第一作者(含共同)在EMBO Journal、Plant Cell、Plant Journal、Plant Cell Environment等国际期刊上发表论文10篇,另参与发表论文10篇,参编教材1部。
办公地址:南京农业大学 生科楼E3002
电子邮箱:likeshen@njau.edu.cn
一、教育和工作经历
2020/12至今,南京农业大学,必赢体育唯一官网,植物生物学系,副教授
2021/11-2022/10,德国维尔茨堡大学, Julius-von-Sachs研究所,访问学者
2013/08-2020/12,南京农业大学,必赢体育唯一官网,植物生物学系,讲师
2006/09 - 2013/06,中国农业大学,生物学院,植物生理与生物化学国家重点实验室,理学博士
2002/09 - 2006/06,南京农业大学,生物技术专业,理学学士
二、教学课程
《植物生理学》、《植物生理学实验》、《文献检索与科技论文写作》等
三、研究方向
1. 植物细胞离子通道、转运体的功能和调控机制
2. 作物养分利用和耐盐性的分子遗传改良
四、招生方向
(1)植物营养生理与分子生物学
(2)植物逆境生理与分子生物学
五、项目课题
(1)国家自然科学基金面上项目,磷脂酸信号调节拟南芥低钾胁迫应答的分子机制,2023/01-2026/12,54万,主持
(2)国家自然科学基金青年科学基金项目,钾转运体OsHAKa在水稻适应盐胁迫过程中的生理功能研究,2015/01-2017/12,24万,主持
(3)江苏省自然科学基金青年基金项目,水稻钾转运体OsHAKx 在响应盐胁迫过程中的转录调控机制研究,2014/07-2016/06,20万,主持
(4)作物遗传与种质创新国家重点实验室自主研究课题,水稻钾离子通道OsAKT2调节水稻耐盐性和生长发育的分子机理,2020/12-2020/12,12.6万,主持
(5)植物生理学与生物化学国家重点实验室开放课题,磷脂酸信号调节水稻钾离子通道OsAKT2活性影响植物生长发育,2019/01-2020/12,5万,主持
(6)国家重点研发计划“政府间国际科技创新合作”项目“水稻绿色多抗技术集成与应用”,2022/06-2025/05,参加
(7)国家自然科学基金面上项目,水稻bHLH类转录因子RST2负调节水稻耐盐性的分子机制,2022/01-2025/12,参加
六、代表性论文(时间倒序,#共同第一作者,*通讯作者)
Wang Ningna, Shi Yiyuan, Jiang Qun, Li Huan, Fan wenxia, Feng Yu, Li Li, Liu Bin, Lin Feng, Jing Wen, Zhang Wenhua*, Shen Like*. (2023) A 14‐3‐3 protein positively regulates rice salt tolerance bystabilizing phospholipase C1. Plant, Cell & Environment, 46: 1232-1248.
Li Jianfang#, Shen Like#, Han Xiuli#, He Gefeng, Fan Wenxia, Li Yu, Yang Shiping, Zhang Ziding, Yang Yongqing, Jin Weiwei, Wang Yi, Zhang Wenhua*, Guo Yan*. (2023) Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress. The EMBO Journal, 2023, e112401
Tian Quanxiang#, Shen Like#*, Luan Junxia, Zhou Zhenzhen, Guo Dongshu, Shen Yue, Jing Wen, Zhang Baolong, Zhang Qun, Zhang Wenhua*. (2021) Rice shaker potassium channel OsAKT2 positively regulates salt tolerance and grain yield by mediating K+ redistribution. Plant, Cell & Environment, 44(9): 2951-2965.
Tian Quanxiang, Luan Junxia, Guo Chunxia, Shi Xingyu, Deng Ping, Zhou Zhenzhen*, Zhang Wenhua, Shen Like*. (2021) A bHLH protein, OsBIM1, positively regulates rice leaf angle by promoting brassinosteroid signaling. Biochemical and Biophysical Research Communications, 2021, 578: 129-135.
Song Tengzhao, Shi Yiyuan, Shen Like, Cao Chengjuan, Shen Yue, Jing Wen, Tian Quanxiang, Lin Feng, Li Wenyu, Zhang Wenhua. (2021) An endoplasmic reticulum–localized cytochrome b5 regulates high-affinity K+ transport in response to salt stress in rice. Proceedings of the National Academy of Sciences, 118(50): e2114347118.
Shen Like*, Tian Quanxiang, Yang Lele, Zhang Hongsheng, Shi Yiyuan, Shen Yue, Zhou Zhenzhen, Wu Qi, Zhang Qun, Zhang Wenhua*. (2020) Phosphatidic acid directly binds with rice potassium channel OsAKT2 to inhibit its activity. The Plant Journal, 102(4): 649-665.
Shen Like*, Yang Lele, Zhang Wenhua. (2020) Multiple basic amino acid residues contribute to phosphatidic acid-mediated inhibition of rice potassium channel OsAKT2. Plant Signaling & Behavior, 15(9): e1789818-4.
Shen Like#, Zhuang Baocheng#, Wu Qi, Zhang Hongsheng, Nie Jianing, Jing Wen, Yang Lele, Zhang Wenhua*. (2019) Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress. Plant Science, 287: 110190
Wei Peipei#, Che Benning#, Shen Like#, Cui Yiqing, Wu Shengyan, Cheng Cong, Liu Feng, Li Man Wah, Yu Bingjun*, Lam Hon Ming*. (2019) Identification and functional characterization of the chloride channel gene, GsCLC-c2 from wild soybean. BMC Plant Biology, 2019, 19: 121.
Wang Peipei, Shen Like, Guo Jinhe, Jing Wen, Qu Yana, Li Wenyu, Bi Rongrong, Xuan Wei, Zhang Qun*, Zhang Wenhua. (2019) Phosphatidic Acid Directly Regulates PINOID-Dependent Phosphorylation and Activation of the PIN-FORMED2 Auxin Efflux Transporter in Response to Salt Stress. The Plant Cell, 31(1): 250-271.
Wang Xueping#, Chen Limei#, Liu Wenxin, Shen Like, Wang Fengliu, Zhou Yuan, Zhang Ziding, Wu Weihua, Wang Yi*. (2016) AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis. Plant Physiology, 170(4): 2264-2277.
Wang Rong, Jing Wen, Xiao Longyun, Jin Yakang, Shen Like, Zhang Wenhua*. (2015) The Rice High-Affinity Potassium Transporter1,1 Is Involved in Salt Tolerance and Regulated by an MYB-Type Transcription Factor. Plant Physiology, 168(3): 1076-1090.
Shen Yue, Shen Like*, Shen Zhenxing, Jing Wen, Ge Hongliang, Zhao Jiangzhe, Zhang Wenhua*. (2015) The potassium transporter OsHAK21 functions in the maintenance of ion homeostasis and tolerance to salt stress in rice. Plant, Cell and Environment, 38(12): 2766-2779.
Maehs Anette, Steinhorst Leonie, Han Jianpu, Shen Like, Wang Yi, Kudla Joerg*. (2013) The Calcineurin B-Like Ca-2 Sensors CBL1 and CBL9 Function in Pollen Germination and Pollen Tube Growth in Arabidopsis. Molecular Plant, 6(4): 1149-1162.
Zhao Lina#, Shen Like#, Zhang Wenzheng#, Zhang Wei#, Wang Yi, Wu Weihua*. (2013) Ca2+-Dependent Protein Kinase11 and 24 Modulate the Activity of the Inward Rectifying K+ Channels in Arabidopsis Pollen Tubes. The Plant Cell, 25(2): 649-661.